Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 20/20 | 0.75 |
| ▸ | MMP13 | P45452 | 5/20 | 0.75 |
| ▸ | MMP2 | P08253 | 1/20 | 0.75 |
| ▸ | MMP3 | P08254 | 1/20 | 0.75 |
| ▸ | MMP7 | P09237 | 1/20 | 0.75 |
| ▸ | MMP9 | P14780 | 1/20 | 0.75 |
| ▸ | MMP8 | P22894 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088727 | 0.86 | MMP12 (0.79) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3088730 | 0.86 | MMP12 (0.79) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3084023 | 0.86 | MMP12 (0.78) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3084022 | 0.86 | MMP12 (0.78) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3081114 | 0.86 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3118632 | 0.83 | MMP12 (0.53) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3079485 | 0.83 | MMP12 (0.93) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL3078021 | 0.81 | MMP12 (0.91) | MMP12MMP13MMP2MMP3MMP7 | |
| SCHEMBL4013118 | 0.80 | MMP12 (0.63) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL3087989 | 0.77 | MMP12 (0.65) | MMP12MMP13MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144893-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137816-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-11-13 | — | — | WO | disclosed |