Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24039007 | 1.00 | NPC1 (0.57) | NPC1RAB9ATP53TSHRNFKB1 | |
| SCHEMBL4048920 | 0.82 | CYP1A2 (0.62) | NOTUMCYP1A2GPR119AKR1B1KMT2A | |
| Bromide SCHEMBL11739258 | 0.81 | CYP1A2 (0.61) | NOTUMCYP1A2GPR119AKR1B1KMT2A | |
| SCHEMBL12171925 | 0.81 | MYC (0.49) | NPC1RAB9ATSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL30419948 | 0.79 | MAPT (0.63) | NPC1RAB9ATP53TSHRSMN1; SMN2 | |
| SCHEMBL25418543 | 0.79 | MAPT (0.63) | NPC1RAB9ATP53TSHRSMN1; SMN2 | |
| SCHEMBL18650263 | 0.79 | NPC1 (0.89) | NPC1RAB9ATP53TSHRNFKB1 | |
| SCHEMBL30420464 | 0.79 | NOTUM (0.50) | NPC1RAB9ATP53TSHRNFKB1 | |
| SCHEMBL25180877 | 0.79 | NOTUM (0.50) | NPC1RAB9ATP53TSHRNFKB1 | |
| SCHEMBL8889786 | 0.75 | CYP1A2 (0.45) | NOTUMCYP1A2GPR119AKR1B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149620-B1 | PYRIDAZINONE COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS INC (US) | 2024-10-23 | — | — | EP | disclosed |