Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | TP53 | P04637 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30419948 | 1.00 | MAPT (0.63) | MAPTTP53NPC1RAB9AL3MBTL1 | |
| SCHEMBL31150586 | 0.84 | MAPT (0.45) | MAPTTP53NPC1RAB9AL3MBTL1 | |
| SCHEMBL25417152 | 0.84 | MAPT (0.45) | MAPTTP53NPC1RAB9AL3MBTL1 | |
| SCHEMBL4048920 | 0.80 | CYP1A2 (0.62) | KMT2AMEN1MAOBNOTUM | |
| SCHEMBL31256752 | 0.79 | NPC1 (0.57) | TP53NPC1RAB9AKMT2ATSHR | |
| SCHEMBL24039007 | 0.79 | NPC1 (0.57) | TP53NPC1RAB9AKMT2ATSHR | |
| Bromide SCHEMBL11739258 | 0.79 | CYP1A2 (0.61) | KMT2AMEN1MAOBNOTUM | |
| SCHEMBL25180877 | 0.74 | NOTUM (0.50) | MAPTTP53NPC1RAB9AKMT2A | |
| SCHEMBL30420464 | 0.74 | NOTUM (0.50) | MAPTTP53NPC1RAB9AKMT2A | |
| SCHEMBL24783657 | 0.73 | LMNA (0.65) | MAPTTP53NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433473-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023091606-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091606-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |