Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883750 | 0.86 | ALDH1A1 (0.64) | ALDH1A1KDM4EGAACYP2C19POLB | |
| SCHEMBL8883742 | 0.86 | ALDH1A1 (0.64) | ALDH1A1KDM4EGAACYP2C19POLB | |
| SCHEMBL31259845 | 0.83 | TNF (0.45) | ALDH1A1MAPTSMN1; SMN2GAACYP2C19 | |
| SCHEMBL6257316 | 0.78 | KDM4E (0.51) | ALDH1A1KDM4EMAPTGAAPOLB | |
| SCHEMBL10693046 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTGAACYP2C19 | |
| SCHEMBL2169473 | 0.77 | TNF (0.50) | ALDH1A1KDM4EGAAPOLBKMT2A | |
| SCHEMBL6261277 | 0.76 | ALDH1A1 (0.72) | ALDH1A1KDM4EMAPTGAACYP2C19 | |
| SCHEMBL31259788 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTGAAPOLB | |
| SCHEMBL2168383 | 0.75 | KMT2A (0.61) | ALDH1A1KDM4EGAAPOLBKMT2A | |
| SCHEMBL672662 | 0.75 | KMT2A (0.61) | ALDH1A1KDM4EGAAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739668-A1 | 1,3-ISOINDOLINEDIONE DERIVATIVES AND HETEROAROMATIC ANALOGUES FOR STIMULATING ENDOTHELIAL CELL-PERICYTE INTERACTION | Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) (NL) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025014359-A1 | 1,3-ISOINDOLINEDIONE DERIVATIVES AND HETEROAROMATIC ANALOGUES FOR STIMULATING ENDOTHELIAL CELL-PERICYTE INTERACTION | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2025-01-16 | — | — | WO | disclosed |