Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302727 | 0.74 | PPARG (0.40) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3248069 | 0.74 | MAPT (0.36) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL3249462 | 0.72 | NPC1 (0.39) | MAPTKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13554406 | 0.67 | CYP3A4 (0.50) | MAPTCYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL11645634 | 0.65 | NPC1 (0.51) | MAPTMEN1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL8339774 | 0.65 | MAPT (0.52) | MAPTL3MBTL1KDM4ERAB9A | |
| SCHEMBL3247157 | 0.65 | CYP2A6 (0.43) | MAPTALDH1A1CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL21851484 | 0.65 | CACNA1H (0.43) | MAPTMEN1KMT2AALDH1A1CYP2D6 | |
| SCHEMBL25299790 | 0.64 | APP (0.39) | MAPTMEN1KMT2AALDH1A1APP | |
| SCHEMBL5329073 | 0.63 | RAB9A (0.67) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |