SCHEMBL3247157

SCHEMBL3247157

c1cncc(-c2ccc3c(n2)CC[N]C3)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.43
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
PTK2 Q05397 1/20 0.42
CYP11B1 P15538 4/20 0.41
CYP11B2 P19099 4/20 0.41
CYP19A1 P11511 2/20 0.41
CYP1A2 P05177 4/20 0.40
CYP3A4 P08684 3/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP2C19 P33261 2/20 0.40
NPC1 O15118 1/20 0.40
CYP2C9 P11712 1/20 0.40
NISCH Q9Y2I1 1/20 0.40
THRB P10828 1/20 0.40
MAPT P10636 1/20 0.39
AXL P30530 1/20 0.39
PBRM1 Q86U86 1/20 0.39
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3246414 0.83 MEN1 (0.41) HSP90AA1CYP3A4ALDH1A1NPC1MAPT
SCHEMBL28024470 0.80 CYP11B1 (0.55) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL4195132 0.77 CHRNB2 (0.44) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL28540727 0.72 CYP2A6 (0.47) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL31310137 0.69 JAK3 (0.48) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL8283777 0.68 CYP1A2 (0.50) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL3194702 0.67 CYP2A6 (0.74) CYP2A6HSP90AA1HSP90AB1PTK2CYP19A1
SCHEMBL13706965 0.67 GRM5 (0.49) CYP2A6HSP90AA1HSP90AB1PTK2CYP11B1
SCHEMBL31259930 0.67 CYP11B1 (0.59) CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9
SCHEMBL14780112 0.67 CYP11B1 (0.59) CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010022055-A2 INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS AMGEN INC. (US) 2010-02-25 WO claimed
WO-2010022055-A2 INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS AMGEN INC. (US) 2010-02-25 WO disclosed