Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31269029 | 0.97 | PDK2 (0.37) | HRH3HRH4PIK3CDPDK2PSEN1 | |
| SCHEMBL31268781 | 0.95 | HRH4 (0.34) | HRH3HRH4PIK3CD | |
| SCHEMBL31269378 | 0.92 | PIK3CD (0.34) | HRH4PIK3CDPDK2PSEN1PSEN2 | |
| SCHEMBL31269323 | 0.91 | HRH4 (0.40) | HRH3HRH4PIK3CD | |
| SCHEMBL31269003 | 0.87 | HRH4 (0.36) | HRH3HRH4PIK3CDPDK2HRH2 | |
| SCHEMBL31269246 | 0.87 | HRH3 (0.35) | HRH3HRH4PIK3CDPDK2HRH2 | |
| SCHEMBL31269010 | 0.87 | HRH3 (0.35) | HRH3HRH4PIK3CDPDK2HRH2 | |
| SCHEMBL31269171 | 0.87 | DRD2 (0.37) | HRH4PIK3CD | |
| SCHEMBL31269456 | 0.87 | CD274 (0.36) | PIK3CD | |
| SCHEMBL30983391 | 0.86 | LTA4H (0.43) | PIK3CDPDK2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |