SCHEMBL31269100

SCHEMBL31269100

Cc1ccnc(Cn2c(-c3ccc(OCC(=O)N(C)C)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 3/20 0.34
▸ PDK2 Q15119 1/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ KCNH2 Q12809 1/20 0.30
▸ SCN5A Q14524 1/20 0.30
▸ SCN9A Q15858 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269275 0.92 KDM4E (0.35) PIK3CDPDK2KDM4ETDP1
SCHEMBL31269396 0.92 PIK3CD (0.33) PIK3CDKDM4ETDP1
SCHEMBL31268819 0.92 PIK3CD (0.36) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268798 0.90 MEN1 (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268938 0.90 KDM4E (0.35) PIK3CDKDM4ETDP1ALDH1A1HSD17B10
SCHEMBL31269457 0.90 SMN1; SMN2 (0.34) PIK3CD
SCHEMBL31268824 0.90 PIK3CD (0.34) PIK3CDPDK2KCNH2SCN5ASCN9A
SCHEMBL31268748 0.89 PIK3CD (0.35) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983502 0.89 NPC1 (0.38) PIK3CDPDK2KDM4EALDH1A1HPGD
SCHEMBL31269352 0.88 PIK3CD (0.37) PIK3CDKDM4ETDP1ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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