SCHEMBL31269396

SCHEMBL31269396

Cc1ccnc(Cn2c(-c3ccc(OCC(=O)N(C)CC4(O)CC4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269100 0.92 PIK3CD (0.34) PIK3CDKDM4ETDP1
SCHEMBL31269275 0.92 KDM4E (0.35) PIK3CDKDM4ETDP1
SCHEMBL31268938 0.91 KDM4E (0.35) PIK3CDKDM4ETDP1
SCHEMBL31268819 0.89 PIK3CD (0.36) PIK3CD
SCHEMBL31269002 0.88 PIK3CD (0.34) PIK3CD
SCHEMBL31269457 0.87 SMN1; SMN2 (0.34) PIK3CD
SCHEMBL31268798 0.87 MEN1 (0.34) PIK3CD
SCHEMBL31269380 0.87 PDE2A (0.38) PIK3CD
SCHEMBL31269352 0.87 PIK3CD (0.37) PIK3CDKDM4ETDP1
SCHEMBL31268824 0.87 PIK3CD (0.34) PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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