SCHEMBL31269185

SCHEMBL31269185

Cc1ccnc(Cn2c(-c3ccc(C(=O)NC4CC4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 7/20 0.38
▸ CNR2 P34972 5/20 0.38
▸ PIK3CD O00329 4/20 0.37
▸ PDE4B Q07343 2/20 0.35
▸ GRM5 P41594 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ LMNA P02545 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ CTDSP1 Q9GZU7 1/20 0.34
▸ MAPK13 O15264 2/20 0.34
▸ DRD4 P21917 1/20 0.34
▸ UTS2R Q9UKP6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269247 0.94 PIK3CD (0.34) CNR1CNR2PIK3CDGRM5LMNA
SCHEMBL31269264 0.94 ABL1 (0.35) CNR1CNR2PIK3CDGRM5
SCHEMBL31268853 0.93 PDE4B (0.35) CNR1CNR2PIK3CDPDE4BGRM5
SCHEMBL31268823 0.93 ABL1 (0.38) CNR1CNR2PIK3CD
SCHEMBL31269478 0.91 SYK (0.36) PIK3CD
SCHEMBL31269475 0.90 PIK3CD (0.37) PIK3CD
SCHEMBL31268954 0.90 PIK3CD (0.35) PIK3CD
SCHEMBL31268793 0.90 PIK3CD (0.35) CNR1CNR2PIK3CD
SCHEMBL31269058 0.90 PIK3CD (0.36) CNR1CNR2PIK3CD
SCHEMBL31269318 0.89 PIK3CD (0.38) CNR1CNR2PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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