SCHEMBL31269321

SCHEMBL31269321

Cc1ccnc(Cn2c(-c3ccc(NC(=O)N(C)C)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 3/20 0.34
▸ APEX1 P27695 1/20 0.34
▸ HSD11B1 P28845 1/20 0.31
▸ KCNH2 Q12809 1/20 0.30
▸ SCN5A Q14524 1/20 0.30
▸ SCN9A Q15858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269047 0.92 PIK3CD (0.36) PIK3CDHSD11B1KCNH2SCN5ASCN9A
SCHEMBL31269266 0.90 PIK3CD (0.35) PIK3CDHSD11B1KCNH2SCN5ASCN9A
SCHEMBL31269339 0.89 PIK3CD (0.34) PIK3CDHSD11B1KCNH2SCN5ASCN9A
SCHEMBL31269219 0.88 PIK3CD (0.33) PIK3CD
SCHEMBL31269182 0.87 PIK3CD (0.36) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268946 0.87 PIK3CD (0.34) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269202 0.87 POLB (0.31) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268748 0.86 PIK3CD (0.35) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269077 0.86 HAVCR2 (0.33) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL30983779 0.84 KCNH2 (0.36) PIK3CDKCNH2SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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