Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122755 | 0.91 | CNR1 (0.39) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL23624594 | 0.91 | CASP3 (0.51) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL12506163 | 0.81 | USP7 (0.47) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL24844836 | 0.81 | USP7 (0.47) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL12505958 | 0.79 | USP7 (0.48) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL12070540 | 0.75 | USP7 (0.48) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL2893441 | 0.74 | CNR1 (0.48) | CNR1CNR2CASP3SENP7SENP6 | |
| Hydrochloric Acid SCHEMBL3833783 | 0.73 | CNR1 (0.47) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL20853351 | 0.72 | GRM5 (0.43) | CNR1CNR2CASP3SENP7SENP6 | |
| SCHEMBL15508611 | 0.72 | GRM5 (0.41) | CNR1CNR2CASP3SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |