Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ASPH | Q12797 | 2/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16475154 | 0.81 | LMNA (0.47) | LMNATDP1POLBMAPTKDM4E | |
| SCHEMBL19330179 | 0.81 | KDM4E (0.59) | LMNATDP1POLBKDM4EASPH | |
| SCHEMBL21818791 | 0.81 | LMNA (0.47) | LMNATDP1POLBKDM4EASPH | |
| SCHEMBL16611528 | 0.80 | LMNA (0.46) | LMNATDP1POLBMAPTKDM4E | |
| SCHEMBL29949269 | 0.80 | LMNA (0.46) | LMNATDP1POLBMAPTKDM4E | |
| SCHEMBL23177321 | 0.80 | LMNA (0.46) | LMNATDP1POLBKDM4EASPH | |
| SCHEMBL6711806 | 0.80 | LMNA (0.46) | LMNATDP1POLBKDM4EASPH | |
| SCHEMBL2004444 | 0.80 | LMNA (0.46) | LMNATDP1POLBMAPTKDM4E | |
| SCHEMBL30592857 | 0.76 | TDP1 (0.57) | LMNATDP1POLBMAPTKDM4E | |
| SCHEMBL18201 | 0.76 | TDP1 (0.57) | LMNATDP1POLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724070-A2 | WRN INHIBITORS | Nimbus Wadjet, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171440-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024254511-A2 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| WO-2024220887-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171440-A1 | WRN INHIBITORS | WRN, BLM, RECQL | LMNA 620/4885TDP1 63/4885POLB 72/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | LMNA 678/4885TDP1 45/4885POLB 86/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | LMNA 678/4885TDP1 45/4885POLB 86/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | LMNA 620/4885TDP1 63/4885POLB 72/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | LMNA 678/4885TDP1 45/4885POLB 86/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | LMNA 692/4885TDP1 39/4885POLB 82/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | LMNA 1670/4885TDP1 106/4885POLB 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.