⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040744 | 0.89 | EPHX1 (0.63) | — | |
| SCHEMBL7430073 | 0.88 | PLG (0.52) | — | |
| SCHEMBL940065 | 0.88 | PLG (0.52) | — | |
| SCHEMBL7024466 | 0.85 | TDP1 (0.64) | — | |
| SCHEMBL15431478 | 0.83 | EPHX1 (0.47) | — | |
| SCHEMBL940066 | 0.82 | TDP1 (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL7418767 | 0.80 | PLG (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL939948 | 0.80 | PLG (0.43) | — | |
| SCHEMBL6294396 | 0.78 | TDP1 (0.39) | — | |
| SCHEMBL12252072 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4694874-A2 | GPX4 INHIBITORS AND SENOLYTIC COMPOUNDS AND USES THEREOF | Rubedo Life Sciences, Inc. (US) | 2026-02-18 | — | — | EP | disclosed |
| US-20260007689-A1 | GPX4 Inhibitors and Senolytic Compounds and Uses Thereof | RUBEDO LIFE SCIENCES INC (US) | 2026-01-08 | — | — | US | disclosed |
| US-12485132-B2 | GPX4 inhibitors and senolytic compounds and uses thereof | Rubedo Life Sciences, Inc. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20250319109-A1 | GPX4 Inhibitors and Senolytic Compounds and Uses Thereof | RUBEDO LIFE SCIENCES INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-20240408124-A1 | GPX4 Inhibitors and Senolytic Compounds and Uses Thereof | Rubedo Life Sciences, Inc. | 2024-12-12 | — | — | US | disclosed |
| WO-2024249613-A2 | GPX4 INHIBITORS AND SENOLYTIC COMPOUNDS AND USES THEREOF | Rubedo Life Sciences, Inc. (US) | 2024-12-05 | — | — | WO | disclosed |