Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270861 | 0.89 | — | — | |
| SCHEMBL7776473 | 0.87 | EPHX1 (0.73) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL5860133 | 0.87 | EPHX1 (0.73) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL15431478 | 0.86 | EPHX1 (0.47) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL22540402 | 0.85 | EPHX1 (0.70) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL7022372 | 0.84 | EPHX1 (0.69) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL7021367 | 0.80 | EPHX1 (0.63) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL8392793 | 0.79 | EPHX1 (0.63) | EPHX1CYP2D6CA2CA12CA1 | |
| SCHEMBL940065 | 0.79 | PLG (0.52) | EPHX1CYP2D6TDP1NPC1RAB9A | |
| SCHEMBL7430073 | 0.79 | PLG (0.52) | EPHX1CYP2D6TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046796-B1 | TETRAHYDROFURO [3, 2 -B]PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2012-10-24 | — | — | EP | disclosed |
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |