Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 3/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31271700 | 0.94 | POLB (0.43) | RORCUSP30TACR1POLBROCK2 | |
| SCHEMBL30694554 | 0.93 | TACR1 (0.45) | RORCUSP30TACR1POLBGPR119 | |
| SCHEMBL21151787 | 0.89 | USP30 (0.54) | RORCUSP30TACR1GPR119ITGB3 | |
| SCHEMBL27332238 | 0.87 | USP30 (0.49) | RORCUSP30TACR1ROCK2GPR119 | |
| SCHEMBL31277323 | 0.87 | USP30 (0.49) | RORCUSP30TACR1ROCK2GPR119 | |
| SCHEMBL31537258 | 0.84 | POLB (0.56) | USP30TACR1POLBGPR119ITGB3 | |
| SCHEMBL31270993 | 0.83 | USP30 (0.43) | RORCUSP30TACR1POLBGPR119 | |
| SCHEMBL21151418 | 0.82 | TACR1 (0.45) | USP30TACR1POLBGPR119ITGB3 | |
| SCHEMBL19534281 | 0.81 | GPR119 (0.51) | USP30TACR1POLBGPR119ITGB3 | |
| SCHEMBL30327653 | 0.80 | TACR1 (0.56) | RORCTACR1POLBGPR119ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249950-A1 | FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN | BIOMEA FUSION, INC. (US) | 2024-12-05 | — | — | WO | disclosed |