Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31271873 | 0.94 | USP30 (0.42) | USP30PRMT5WDR77TACR1IMPDH2 | |
| SCHEMBL30694514 | 0.94 | USP30 (0.44) | USP30PRMT5WDR77TACR1ITGB3 | |
| SCHEMBL31270940 | 0.83 | RORC (0.46) | USP30TACR1ITGB3ITGA2BPOLB | |
| SCHEMBL21151787 | 0.82 | USP30 (0.54) | USP30TACR1ITGB3ITGA2BGPR119 | |
| SCHEMBL23538742 | 0.79 | USP30 (0.46) | USP30ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL16936740 | 0.79 | USP30 (0.47) | USP30PRMT5WDR77AAK1SCD5 | |
| SCHEMBL26097489 | 0.78 | CYP11B2 (0.46) | USP30ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL31537258 | 0.78 | POLB (0.56) | USP30TACR1ITGB3ITGA2BPOLB | |
| SCHEMBL23539023 | 0.78 | CYP3A4 (0.48) | USP30ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL31271700 | 0.77 | POLB (0.43) | USP30TACR1POLBGPR119RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249950-A1 | FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN | BIOMEA FUSION, INC. (US) | 2024-12-05 | — | — | WO | disclosed |