SCHEMBL3127698

SCHEMBL3127698

NC(=O)c1ccccc1S(=O)(=O)Nc1nccs1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.53
PTGS1 P23219 1/20 0.53
SCN9A Q15858 4/20 0.53
ALDH1A1 P00352 3/20 0.51
LMNA P02545 2/20 0.51
KDM4E B2RXH2 1/20 0.51
CYP2C9 P11712 1/20 0.51
EDNRA P25101 1/20 0.51
SLC6A4 P31645 1/20 0.51
ADRA1A P35348 1/20 0.51
PRMT6 Q96LA8 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
USP2 O75604 1/20 0.50
MAPT P10636 1/20 0.50
ESR2 Q92731 1/20 0.50
HSD17B10 Q99714 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.49
NPC1 O15118 1/20 0.49
GAA P10253 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10420368 0.84 SLC40A1 (0.56) CYP3A4PTGS1ALDH1A1USP2MAPT
SCHEMBL1492421 0.80 ALDH1A1 (0.60) SCN9AALDH1A1LMNAKDM4ECYP2C9
SCHEMBL29494648 0.80 ALDH1A1 (0.60) SCN9AALDH1A1LMNAKDM4ECYP2C9
SCHEMBL30015045 0.77 ALDH1A1 (0.54) SCN9AALDH1A1LMNATDP1SMN1; SMN2
SCHEMBL1094208 0.77 SCN9A (0.61) SCN9AUSP2MAPTESR2HSD17B10
SCHEMBL29668582 0.77 SCN9A (0.61) SCN9AUSP2MAPTESR2HSD17B10
SCHEMBL22567942 0.77 USP2 (0.70) SCN9AALDH1A1LMNAKDM4ECYP2C9
SCHEMBL4169039 0.76 SCN3A (0.51) CYP3A4PTGS1SCN9AALDH1A1SMN1; SMN2
SCHEMBL3278437 0.75 ALDH1A1 (0.69) ALDH1A1LMNAKDM4ECYP2C9EDNRA
SCHEMBL1093393 0.74 SCN5A (0.56) SCN9AALDH1A1LMNAKDM4ECYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541588-B2 Sulfonamide derivatives PFIZER LIMITED (GB) 2013-09-24 US disclosed
WO-2010035166-A1 BENZAMIDE DERIVATIVES PFIZER LIMITED (GB) 2010-04-01 WO disclosed