Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22229882 | 0.74 | SRD5A1 (0.38) | CRBN | |
| SCHEMBL22609513 | 0.73 | DDB1 (0.41) | DDB1CRBNIKZF3MKNK1MKNK2 | |
| SCHEMBL29991276 | 0.73 | DDB1 (0.41) | DDB1CRBNIKZF3MKNK1MKNK2 | |
| SCHEMBL1249938 | 0.66 | TDP1 (0.42) | MKNK1IRAK4ALDH1A1POLBKDM4E | |
| SCHEMBL9449531 | 0.65 | TDP1 (0.44) | DDB1CRBNIKZF3POLBHSD17B10 | |
| SCHEMBL3290233 | 0.65 | DRD2 (0.57) | DDB1CRBNIKZF3MKNK1IRAK4 | |
| Hydrochloric Acid SCHEMBL4919274 | 0.64 | DRD2 (0.56) | DDB1CRBNIKZF3MKNK1IRAK4 | |
| Hydrochloric Acid SCHEMBL29398597 | 0.64 | DRD2 (0.56) | DDB1CRBNIKZF3MKNK1IRAK4 | |
| Hydrochloric Acid SCHEMBL7655718 | 0.64 | DRD2 (0.56) | DDB1CRBNIKZF3MKNK1IRAK4 | |
| SCHEMBL7196401 | 0.64 | TDP1 (0.58) | POLBHSD17B10HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |