Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 11/20 | 0.46 |
| ▸ | GRM5 | P41594 | 11/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867692 | 0.89 | GRM1 (0.45) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL31282887 | 0.87 | GRM1 (0.44) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL31283106 | 0.82 | GRM1 (0.49) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL31703329 | 0.79 | PDK4 (0.51) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL15024195 | 0.74 | GRM1 (0.60) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL4011645 | 0.74 | GRM1 (0.51) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL18755022 | 0.73 | PDK4 (0.53) | GRM1GRM5PDK4TNK2NAMPT | |
| SCHEMBL12883596 | 0.73 | PDK4 (0.53) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL3466789 | 0.73 | PDK4 (0.58) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL31227073 | 0.73 | WNT3A (0.61) | GRM1GRM5PDK4TNK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705293-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2025217247-A1 | TETHERED SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2025-10-16 | — | — | WO | disclosed |
| WO-2024229317-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-11-07 | — | — | WO | disclosed |