Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.45 |
| ▸ | GRM5 | P41594 | 10/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31283409 | 0.89 | GRM1 (0.46) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL31282887 | 0.85 | GRM1 (0.44) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL30867776 | 0.82 | CHRNA7 (0.31) | GRM1GRM5PDK4 | |
| SCHEMBL31283106 | 0.82 | GRM1 (0.49) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL30867684 | 0.81 | MAP4K4 (0.33) | — | |
| SCHEMBL31703329 | 0.77 | PDK4 (0.51) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL30867920 | 0.76 | GPR119 (0.43) | WNT3A | |
| SCHEMBL30867713 | 0.76 | MAP4K4 (0.31) | — | |
| SCHEMBL15024195 | 0.73 | GRM1 (0.60) | GRM1GRM5PDK4TNK2CCNT1 | |
| SCHEMBL18755022 | 0.72 | PDK4 (0.53) | GRM1GRM5PDK4TNK2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598916-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |