Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867784 | 0.82 | GPR119 (0.41) | POLBGPR119HDAC4CKS1BSKP1 | |
| SCHEMBL1580434 | 0.77 | GPR119 (0.48) | POLBGPR119HDAC4CKS1BSKP1 | |
| SCHEMBL29668815 | 0.77 | GPR119 (0.48) | POLBGPR119HDAC4CKS1BSKP1 | |
| SCHEMBL30867722 | 0.76 | KHK (0.38) | POLBGPR119HDAC4CKS1BSKP1 | |
| SCHEMBL38654229 | 0.76 | KHK (0.38) | POLBGPR119HDAC4CKS1BSKP1 | |
| SCHEMBL3991539 | 0.75 | CKS1B (0.50) | POLBGPR119CKS1BSKP1SKP2 | |
| SCHEMBL24851452 | 0.74 | CKS1B (0.49) | POLBGPR119CKS1BSKP1SKP2 | |
| SCHEMBL1280129 | 0.74 | GPR119 (0.56) | POLBGPR119CKS1BSKP1SKP2 | |
| SCHEMBL30162245 | 0.74 | CKS1B (0.49) | POLBGPR119CKS1BSKP1SKP2 | |
| SCHEMBL15390642 | 0.74 | ALDH1A1 (0.50) | GPR119HDAC4MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705293-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024229317-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-11-07 | — | — | WO | disclosed |