Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131583 | 0.92 | MEN1 (0.39) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3119888 | 0.90 | MEN1 (0.38) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL27810967 | 0.84 | MEN1 (0.40) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3130261 | 0.84 | MEN1 (0.62) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3117167 | 0.83 | CHRNA7 (0.42) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3128663 | 0.82 | MEN1 (0.43) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3127436 | 0.81 | SGMS2 (0.37) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL27810966 | 0.80 | MEN1 (0.40) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL28784609 | 0.77 | MEN1 (0.42) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL3128687 | 0.76 | MEN1 (0.56) | MEN1KMT2AMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164846-A2 | HETEROARYL SUBSTITUTED THIAZOLES AND THEIR USE AS ANTIVIRAL AGENTS. | Achillion Pharmaceuticals, Inc. (US) | 2010-03-24 | — | — | EP | claimed |
| WO-2008147557-A2 | HETEROARYL SUBSTITUTED THIAZOLES AND THEIR USE AS ANTIVIRAL AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | claimed |