Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31289703 | 0.84 | CYP3A4 (0.44) | POLBTDP1KDM4EMAPTMAPK1 | |
| SCHEMBL21826454 | 0.80 | KDM4E (0.38) | POLBTDP1KDM4EKMT2AMAPT | |
| SCHEMBL23723880 | 0.75 | AGXT (0.34) | POLBMAPTRECQLCYP3A4CASP1 | |
| SCHEMBL30105437 | 0.75 | AGXT (0.34) | POLBMAPTRECQLCYP3A4CASP1 | |
| SCHEMBL676649 | 0.74 | KDM4E (0.43) | POLBTDP1KDM4EKMT2AMAPK1 | |
| SCHEMBL9952844 | 0.74 | POLB (0.38) | POLBTDP1KDM4EKMT2ACA12 | |
| SCHEMBL31434974 | 0.74 | REN (0.40) | PKM | |
| SCHEMBL12794738 | 0.73 | POLB (0.43) | POLBTDP1KDM4EMAPK1CA12 | |
| SCHEMBL8599315 | 0.72 | POLB (0.46) | POLBTDP1KDM4EMAPK1CA12 | |
| SCHEMBL23723621 | 0.72 | KCNJ5 (0.33) | MAPK1RECQLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724070-A2 | WRN INHIBITORS | Nimbus Wadjet, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250206738-A1 | WRN INHIBITORS | NIMBUS DISCOVERY, INC. | 2025-06-26 | — | — | US | disclosed |
| WO-2025137599-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171440-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024254511-A2 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206738-A1 | WRN INHIBITORS | WRN, BLM, RECQL | POLB 86/4885TDP1 45/4885KDM4E 3350/4885 |
| US-20250171440-A1 | WRN INHIBITORS | WRN, BLM, RECQL | POLB 72/4885TDP1 63/4885KDM4E 2662/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | POLB 86/4885TDP1 45/4885KDM4E 3350/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | POLB 86/4885TDP1 45/4885KDM4E 3350/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | POLB 72/4885TDP1 63/4885KDM4E 2662/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | POLB 86/4885TDP1 45/4885KDM4E 3350/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | POLB 82/4885TDP1 39/4885KDM4E 3415/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | POLB 193/4885TDP1 106/4885KDM4E 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.