Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31637434 | 0.85 | SCN9A (0.40) | REN | |
| SCHEMBL31637458 | 0.84 | PKM (0.38) | RENPKMMKNK1MKNK2 | |
| SCHEMBL31493475 | 0.83 | LRRK2 (0.39) | RENPKM | |
| SCHEMBL31596392 | 0.77 | CFTR (0.44) | RENPKM | |
| SCHEMBL31637789 | 0.74 | HCRTR2 (0.31) | — | |
| SCHEMBL31289966 | 0.74 | POLB (0.39) | PKM | |
| SCHEMBL31289703 | 0.72 | CYP3A4 (0.44) | PKM | |
| SCHEMBL2929331 | 0.69 | SIGMAR1 (0.46) | REN | |
| SCHEMBL16731359 | 0.66 | SIGMAR1 (0.54) | REN | |
| SCHEMBL19145262 | 0.66 | SIGMAR1 (0.46) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250206738-A1 | WRN INHIBITORS | NIMBUS DISCOVERY, INC. | 2025-06-26 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-04-24 | — | — | US | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206738-A1 | WRN INHIBITORS | WRN, BLM, RECQL | REN 3104/4885PKM 3180/4885MKNK1 1262/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | REN 3104/4885PKM 3180/4885MKNK1 1262/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | REN 3104/4885PKM 3180/4885MKNK1 1262/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | REN 2910/4885PKM 3266/4885MKNK1 1426/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | REN 3104/4885PKM 3180/4885MKNK1 1262/4885 |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | WRN, BLM, RECQL | REN 3009/4885PKM 3083/4885MKNK1 750/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | REN 2984/4885PKM 3254/4885MKNK1 1323/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | REN 1035/4885PKM 3500/4885MKNK1 1222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.