SCHEMBL31292007

SCHEMBL31292007

COc1cc(OC)cc(N(Cc2ccc(F)cc2)C(=O)/C=C/c2csc(C#C[Si](C(C)C)(C(C)C)C(C)C)n2)c1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 2/20 0.36
NR1H4 Q96RI1 6/20 0.36
MAPK14 Q16539 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KMT2A Q03164 1/20 0.32
BCL2A1 Q16548 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31291832 0.87 HDAC3 (0.42) TRPM8NR1H4LMNAMAPTSMN1; SMN2
SCHEMBL31291991 0.84 TRPM8 (0.43) TRPM8NR1H4LMNAMAPTSMN1; SMN2
SCHEMBL31291800 0.79 CYP1B1 (0.32) LMNAMAPTSMN1; SMN2KMT2A
SCHEMBL31291968 0.76 MAPK14 (0.38) NR1H4MAPK14KMT2A
SCHEMBL25074071 0.66 RNF4 (0.55) LMNAMAPTSMN1; SMN2BCL2A1
SCHEMBL31291990 0.64 CYP1B1 (0.35) LMNAMAPTSMN1; SMN2KMT2A
SCHEMBL31291881 0.63 MEN1 (0.43) MAPK14LMNAKMT2A
SCHEMBL31291986 0.61 MEN1 (0.43) MAPK14LMNAMAPTKMT2A
SCHEMBL31186711 0.61 TSPO (0.55) LMNASMN1; SMN2KMT2ABCL2A1
SCHEMBL31186717 0.61 RNF4 (0.51) LMNAMAPTSMN1; SMN2BCL2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025030117-A1 FERROPTOSIS INDUCERS ARPEGGIO BIOSCIENCES, INC. (US) 2025-02-06 WO disclosed