Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31292798 | 0.90 | JAK2 (0.47) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL31293172 | 0.83 | USP30 (0.41) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL22750434 | 0.82 | GPR119 (0.59) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL22750432 | 0.82 | GPR119 (0.59) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL22750429 | 0.82 | GPR119 (0.59) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL23751448 | 0.82 | GPR119 (0.59) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL31292816 | 0.81 | USP30 (0.40) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL31293104 | 0.81 | EPHA2 (0.42) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL30923017 | 0.81 | MEN1 (0.46) | JAK2JAK1GPR119GAATHRB | |
| SCHEMBL3185439 | 0.80 | USP30 (0.45) | JAK2JAK1GPR119GAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747236-A1 | PIPERIDINE, MORPHOLINE AND TETRAHYDRO-PYRIDAZINE COMPOUNDS WITH LP(A) LOWERING ACTIVITY | Eli Lilly and Company (US) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025024210-A1 | PIPERIDINE, MORPHOLINE AND TETRAHYDRO-PYRIDAZINE COMPOUNDS WITH LP(A) LOWERING ACTIVITY | ELI LILLY AND COMPANY (US) | 2025-01-30 | — | — | WO | disclosed |