SCHEMBL31294087

SCHEMBL31294087

CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4c(c3)NC(=O)C(F)(F)O4)n2)=C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SYK P43405 19/20 1.00
JAK2 O60674 1/20 0.71
EGFR P00533 1/20 0.71
LCK P06239 1/20 0.71
LYN P07948 1/20 0.71
FGFR4 P22455 1/20 0.71
JAK1 P23458 1/20 0.47
JAK3 P52333 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29794592 0.93 SYK (1.00) SYKJAK2EGFRLCKLYN
R-343 SCHEMBL2037260 0.83 SYK (1.00) SYKJAK2EGFRLCKLYN
R-343 SCHEMBL31060361 0.83 SYK (1.00) SYKJAK2EGFRLCKLYN
SCHEMBL1198156 0.82 SYK (0.77) SYKJAK2EGFRLCKLYN
SCHEMBL30010055 0.80 SYK (1.00) SYK
SCHEMBL30009798 0.78 SYK (1.00) SYK
SCHEMBL12872816 0.77 SYK (0.88) SYKJAK2EGFRLCKLYN
SCHEMBL30010438 0.77 SYK (1.00) SYK
SCHEMBL13007740 0.76 SYK (0.83) SYKJAK2EGFRLCKLYN
SCHEMBL2101538 0.76 SYK (0.69) SYKJAK2EGFRLCKLYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114945378-B Feeder-based and feeder-free stem cell culture systems for stratified epithelial stem cells and related uses thereof 休斯敦大学体系 2024-11-19 CN disclosed