SCHEMBL31296532

SCHEMBL31296532

CC(C)(C)OC(=O)NCCOc1ccccc1-c1cc(N)c(F)cc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.50
PDK2 Q15119 1/20 0.48
ALOX5AP P20292 1/20 0.45
FEN1 P39748 1/20 0.45
CA12 O43570 3/20 0.44
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA9 Q16790 3/20 0.44
RAB9A P51151 3/20 0.43
KMT2A Q03164 1/20 0.43
IDO1 P14902 2/20 0.41
MALT1 Q9UDY8 1/20 0.41
ATM Q13315 2/20 0.40
NPC1 O15118 2/20 0.39
EGFR P00533 1/20 0.39
ITK Q08881 1/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 1/20 0.39
DRD2 P14416 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25470614 1.00 SCN9A (0.50) SCN9APDK2ALOX5APFEN1CA12
SCHEMBL26623997 0.87 SCN9A (0.50) SCN9APDK2ALOX5APFEN1CA12
SCHEMBL26623850 0.86 SCN9A (0.49) SCN9APDK2ALOX5APFEN1CA12
SCHEMBL26623996 0.85 SCN9A (0.48) SCN9APDK2ALOX5APFEN1CA12
SCHEMBL30642436 0.85 SCN9A (0.48) SCN9APDK2ALOX5APFEN1CA12
SCHEMBL26624030 0.84 RAB9A (0.43) ALOX5APFEN1RAB9AKMT2ANPC1
SCHEMBL7425171 0.80 RAB9A (0.63) SCN9APDK2CA12CA1CA2
SCHEMBL25470355 0.80 KCNA5 (0.52) PDK2ALOX5APFEN1IDO1MALT1
SCHEMBL25470761 0.80 MALT1 (0.45) SCN9APDK2ALOX5APFEN1IDO1
SCHEMBL26623874 0.79 SCN9A (0.45) SCN9APDK2ALOX5APFEN1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119137107-A Macrocyclic inhibitors of ATP citrate lyase 艾斯柏伦治疗公司 2024-12-13 CN disclosed