Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675216 | 0.76 | KDM4E (0.96) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL29232846 | 0.73 | ALDH1A1 (0.74) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL28034715 | 0.73 | ALDH1A1 (0.68) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL27638183 | 0.72 | MAPT (0.57) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL24921161 | 0.71 | MAPT (0.56) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL27601818 | 0.71 | ALDH1A1 (0.58) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL12924604 | 0.71 | NOTUM (0.60) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL16982635 | 0.71 | NOTUM (0.64) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL721861 | 0.71 | ACHE (0.65) | MAPTALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL4581181 | 0.70 | NOTUM (0.65) | MAPTALDH1A1HPGDMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955602-A | Celastrol split heterocyclic derivative and application thereof | 延边大学 | 2024-11-15 | — | — | CN | disclosed |