SCHEMBL31301360

SCHEMBL31301360

CN(C(=O)c1cncc(-c2ccc(C(F)(F)F)cc2)n1)c1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 5/20 0.53
SCN10A Q9Y5Y9 6/20 0.46
SCN2A Q99250 4/20 0.46
LIPE Q05469 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
MLYCD O95822 1/20 0.41
PIK3CD O00329 1/20 0.40
PIK3CB P42338 1/20 0.40
PI4KA P42356 1/20 0.40
PIK3CG P48736 1/20 0.40
PIK3C3 Q8NEB9 1/20 0.40
P2RX1 P51575 1/20 0.40
LTC4S Q16873 1/20 0.39
SCN9A Q15858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301522 0.92 GPBAR1 (0.46) GPBAR1SCN10ASCN2ALIPEMEN1
SCHEMBL31301435 0.91 SCN10A (0.53) GPBAR1SCN10ASCN2AMEN1KMT2A
SCHEMBL31301363 0.90 GPBAR1 (0.42) GPBAR1SCN10AMLYCDSCN9A
SCHEMBL31301619 0.90 MLYCD (0.46) GPBAR1SCN10ASCN2AKMT2AMLYCD
SCHEMBL31301526 0.88 GPBAR1 (0.41) GPBAR1SCN10ASCN2AMLYCDLTC4S
SCHEMBL31301342 0.87 MEN1 (0.43) GPBAR1SCN10ASCN2ALIPEMEN1
SCHEMBL31301539 0.87 SCN10A (0.44) GPBAR1SCN10ASCN2ALTC4SSCN9A
SCHEMBL31301346 0.86 SCN10A (0.55) GPBAR1SCN10ASCN2AMEN1KMT2A
SCHEMBL31301480 0.86 SCN10A (0.55) GPBAR1SCN10ASCN2AMEN1KMT2A
SCHEMBL31301449 0.86 SCN10A (0.41) GPBAR1SCN10ASCN2ALIPEKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS GPBAR1 803/4885SCN10A 3171/4885SCN2A 2686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.