SCHEMBL31301375

SCHEMBL31301375

Cc1ccc(N(C)C(=O)c2cncc(-c3ccc(C(F)(F)F)cc3)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 2/20 0.48
HDAC1 Q13547 3/20 0.46
KDM1A O60341 1/20 0.46
GPBAR1 Q8TDU6 5/20 0.45
LIPE Q05469 1/20 0.43
MCHR1 Q99705 1/20 0.42
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
SCN10A Q9Y5Y9 2/20 0.41
HSD17B1 P14061 2/20 0.40
HSD17B2 P37059 2/20 0.40
CHRNA7 P36544 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301568 0.89 GPBAR1 (0.54) MLYCDHDAC1KDM1AGPBAR1LIPE
SCHEMBL31301548 0.84 SCN10A (0.54) HDAC1GPBAR1SCN10AHSD17B1HSD17B2
SCHEMBL31301583 0.82 GPBAR1 (0.47) MLYCDHDAC1KDM1AGPBAR1LIPE
SCHEMBL31301417 0.78 MAP4K4 (0.52) GPBAR1SCN10A
SCHEMBL13876033 0.75 KDM1A (0.54) HDAC1KDM1ASCN10A
SCHEMBL31301420 0.75 MKNK1 (0.62) HDAC1KDM1A
SCHEMBL1843427 0.75 MKNK1 (0.62) HDAC1KDM1A
SCHEMBL640848 0.74 MKNK1 (0.60) HDAC1KDM1A
SCHEMBL30108269 0.74 MKNK1 (0.60) HDAC1KDM1A
SCHEMBL640445 0.73 CYP11B1 (0.58) HDAC1KDM1ASCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS MLYCD 2142/4885HDAC1 1273/4885KDM1A 3809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.