SCHEMBL31301422

SCHEMBL31301422

[2H]C([2H])([2H])N(C(=O)c1cncc(-c2ccc(OC(F)(F)F)cc2)n1)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 11/20 0.52
SCN2A Q99250 8/20 0.50
ABL1 P00519 2/20 0.48
DHODH Q02127 1/20 0.41
ALOX5 P09917 1/20 0.39
TP53 P04637 1/20 0.38
GRIN2B Q13224 1/20 0.38
LIPE Q05469 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301261 0.93 SCN10A (0.55) SCN10ASCN2AABL1DHODHALOX5
SCHEMBL31301522 0.87 GPBAR1 (0.46) SCN10ASCN2AALOX5LIPE
SCHEMBL31301398 0.85 SCN10A (0.50) SCN10ASCN2AABL1DHODH
SCHEMBL31301271 0.84 SCN10A (0.52) SCN10ASCN2AABL1DHODHGRIN2B
SCHEMBL31301486 0.84 SCN10A (0.52) SCN10ASCN2AABL1DHODHALOX5
SCHEMBL31301435 0.80 SCN10A (0.53) SCN10ASCN2A
SCHEMBL31301594 0.80 SCN10A (0.52) SCN10ASCN2AABL1DHODHGRIN2B
SCHEMBL31301360 0.79 GPBAR1 (0.53) SCN10ASCN2ALIPE
SCHEMBL31301275 0.78 SCN10A (0.46) SCN10ASCN2A
SCHEMBL31301480 0.76 SCN10A (0.55) SCN10ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS SCN10A 3171/4885SCN2A 2686/4885ABL1 524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.