SCHEMBL31301528

SCHEMBL31301528

O=C(Nc1ccc(C2CC2)cc1)c1cncc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 4/20 0.51
ABL1 P00519 1/20 0.51
MCHR1 Q99705 2/20 0.49
SCN10A Q9Y5Y9 4/20 0.48
SCN2A Q99250 3/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
MAPK1 P28482 1/20 0.47
TRPV1 Q8NER1 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301529 0.85 SCN10A (0.63) ABL1SCN10ASCN2ALMNAMAPT
SCHEMBL31301643 0.85 ABL1 (0.56) ABL1SCN10ASCN2ALMNAMAPT
SCHEMBL31301597 0.81 SCN10A (0.52) ABL1SCN10ASCN2ALMNAMAPT
SCHEMBL31301343 0.80 KCNQ3 (0.66) ABL1SCN10ASCN2ALMNAMAPT
SCHEMBL31301458 0.79 SCN10A (0.54) ABL1MCHR1SCN10ASCN2ALMNA
SCHEMBL31301446 0.79 DGAT1 (0.49) DGAT1
SCHEMBL34461780 0.78 SCN10A (0.51) ABL1MCHR1SCN10ASCN2A
SCHEMBL31301527 0.74 SCN10A (0.46) ABL1SCN10ASCN2ALMNAMAPT
SCHEMBL31301356 0.73 PARP1 (0.44) SCN10AMAPTTRPV1
SCHEMBL16420770 0.71 ATR (0.66) SCN10ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS DGAT1 1115/4885ABL1 524/4885MCHR1 1507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.