SCHEMBL313036

SCHEMBL313036

Cc1cn([C@]2([SiH](c3ccccc3)c3ccccc3)O[C@H](COC(C)(C)C)[C@@H](O)[C@H]2OCCON(C)C)c(=O)[nH]c1=O

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.32
TK2 O00142 8/20 0.32
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1738254 0.93 TK1 (0.31) TK1TK2
SCHEMBL7901421 0.92 TK1 (0.32) TK1
SCHEMBL261290 0.91 TK1 (0.33) TK1TK2HPGD
SCHEMBL7247157 0.91 TK1 (0.32) TK1TK2HPGD
SCHEMBL8172947 0.85 TK1 (0.33) TK1TK2HPGD
SCHEMBL7065023 0.84 TK1 (0.33) TK1TK2HPGD
SCHEMBL8171836 0.83 TK1 (0.33) TK1
SCHEMBL3516066 0.81 TK2 (0.32) TK1TK2HPGD
SCHEMBL10646812 0.78
SCHEMBL10647181 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 765 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2270024-B1 Antisense modulation of superoxide dismutase 1, soluble expression IONIS PHARMACEUTICALS INC (US) 2018-10-24 EP disclosed
US-20180094260-A1 EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS KASTLE THERAPEUTICS, LLC (US) 2018-04-05 US disclosed
US-20170355986-A1 ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION KASTLE THERAPEUTICS, LLC (US) 2017-12-14 US disclosed
US-9476051-B2 Antisense modulation of superoxide dismutase 1, soluble expression IONIS PHARMACEUTICALS, INC. (US) 2016-10-25 US disclosed
US-9371530-B2 Modulation of growth hormone receptor expression and insulin-like growth factor expression ANTISENSE THERAPEUTICS LTD. (AU) 2016-06-21 US disclosed
US-20150322429-A1 SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION COMERICA BANK 2015-11-12 US disclosed
US-20150232838-A1 EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS COMERICA BANK 2015-08-20 US disclosed
US-9084770-B2 Modulation of insulin like growth factor I receptor expression in cancer ANTISENSE THERAPEUTICS, LTD. (AU) 2015-07-21 US disclosed
US-20150167008-A1 ANTISENSE MODULATION OF SUPEROXIDE DISMUTASE 1, SOLUBLE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2015-06-18 US disclosed
EP-2365094-B1 Antisense modulation of PTP1B expression ISIS PHARMACEUTICALS INC (US) 2015-04-22 EP disclosed
US-5985664-A ANTISENSE OLIGONUCLEOTIDES, TARGETED TO NUCLEIC ACIDS ENCODING SENTRIN ISIS PHARMACEUTICALS, INC. (US) 1999-11-16 US disclosed
US-5981732-A ANTISENSE OLIGONUCLEOTIDES WHICH TARGET THE EXPRESSION OF A G PROTEIN ISIS PHARMACEUTICALS INC. (US) 1999-11-09 US disclosed
US-5977341-A Antisense modulation of inhibitor-kappa B kinase-beta expression ISIS PHARMACEUTICALS INC. (US) 1999-11-02 US disclosed
US-5962673-A ANTISENSE AGENT 8 TO 30 NUCLEOBASES IN LENGTH; FOR DIAGNOSIS AND TREATMENT OF ASTHMA, MYASTHENIA GRAVIS, GRAVES' DISEASE, ALLOGRAFT REJECTION, PSORIASIS AND OTHERS; ANTITUMOR/ ANTIPROLIFERATIVE/ANTIDIABETIC/ANTIARTHRITIC AGENTS ISIS PHARMACEUTICALS INC. (US) 1999-10-05 US disclosed
US-5958772-A TARGETS TO NUCLEIC ACID MOLECULE ENCODING HUMAN CELLULAR INHIBITORS OF APOTOPSIS-1 ISIS PHARMACEUTICALS INC. (US) 1999-09-28 US disclosed
US-5959097-A OLIGONUCLEOTIDE OF 8 TO 30 NUCLEOTIDES WHICH SUPPRESSES EXPRESSION OF SIGNAL TRANSDUCTION KINASE; FOR TREATMENT OF INFECTIONS; ANTIINFLAMMATORY/ANTITUMOR AGENTS ISIS PHARMACEUTICALS, INC. (US) 1999-09-28 US disclosed
US-5958773-A ANTISENSE COMPOUND 8 TO 30 NUCLEOTIDES IN LENGTH TARGETED TO A NUCLEIC ACID ENCODING HUMAN AKT-1, OF THE SERINE/THREONINE KINASE FAMILY INVOLVED IN SIGNALLING PATHWAYS; INHIBITING EXPRESSION OF AKT-1 WITH THE ANTISENSE COMPOUND ISIS PHARMACEUTICALS INC. (US) 1999-09-28 US disclosed
US-5958771-A OLIGONUCLEOTIDE FROM 8 TO 30 NUCLEOTIDES IN LENGTH; FOR DIAGNOSIS AND THERAPY; ANTITUMOR/ANTIINFLAMMATORY AGENTS ISIS PHARMACEUTICALS, INC. (US) 1999-09-28 US disclosed
US-5951455-A OLIGONUCLEOTIDES, TARGETED TO NUCLEIC ACIDS WITH MODULATION AND EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1999-09-14 US disclosed
US-5948680-A ANTISENSE OLIGONUCLEOTIDE TARGETED TO NUCLEIC ACIDS ENCODING ELK-1; ANTIPROLIFERATIVE AGENTS ISIS PHARMACEUTICALS INC. (US) 1999-09-07 US disclosed