Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313036 | 0.92 | TK1 (0.32) | TK1 | |
| SCHEMBL8171836 | 0.92 | TK1 (0.33) | TK1 | |
| SCHEMBL1738254 | 0.87 | TK1 (0.31) | TK1 | |
| SCHEMBL261290 | 0.83 | TK1 (0.33) | TK1 | |
| SCHEMBL7247157 | 0.82 | TK1 (0.32) | TK1 | |
| SCHEMBL10646812 | 0.82 | — | — | |
| SCHEMBL10647168 | 0.79 | TK1 (0.31) | TK1 | |
| SCHEMBL7066649 | 0.78 | KDM4E (0.37) | — | |
| SCHEMBL10645242 | 0.78 | — | — | |
| SCHEMBL10643490 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187586-B1 | NUCLEOTIDE SEQUENCE OF COMPOUND WHICH INHIBITS EXPRESSION OF HUMAN SERINE/THREONINE KINASE INVOLVED IN SIGNAL TRANSDUCTION; DIAGNOSIS, PROPHYLAXIS, AND THERAPY OF RELATED DISEASES | ISIS PHARMACEUTICALS, INC. | 2001-02-13 | — | — | US | disclosed |
| US-6140125-A | NUCLEOTIDE SEQUENCES WHICH TARGET START CODON AND UNTRANSLATED POSITIONING OF A CODED PROTEIN; FOR THE DIAGNOSIS OF TUMORS AND INFLAMMATION; ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS | ISIS PHARMACEUTICALS INC. (US) | 2000-10-31 | — | — | US | disclosed |
| US-6140126-A | OLIGONUCLEOTIDES WHICH TARGET UNTRANSLATED REGIONS CODING A TRANSCRIPTION FACTOR; FOR TREATMENT OF CANCER AND INFLAMAMATION; ANTICARCINOGENIC AGENTS; ANTIINFLAMMATORY AGENTS | ISIS PHARMACEUTICALS INC. (US) | 2000-10-31 | — | — | US | disclosed |
| US-5951455-A | OLIGONUCLEOTIDES, TARGETED TO NUCLEIC ACIDS WITH MODULATION AND EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1999-09-14 | — | — | US | disclosed |