Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31307581 | 0.86 | SREBF2 (0.44) | SREBF2CYP17A1TDP1MAPTNPY1R | |
| SCHEMBL31717344 | 0.84 | SREBF2 (0.48) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL2025129 | 0.84 | ALDH1A1 (0.57) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL31307597 | 0.83 | SREBF2 (0.47) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL25361898 | 0.81 | HDAC1 (0.54) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL25360717 | 0.79 | RAB9A (0.57) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL26013556 | 0.77 | HDAC1 (0.52) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL25361542 | 0.77 | SREBF2 (0.48) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL25363985 | 0.76 | TDP1 (0.48) | SREBF2CYP17A1TDP1PSMB8MAPT | |
| SCHEMBL25360393 | 0.76 | TDP1 (0.48) | SREBF2CYP17A1TDP1PSMB8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301105-A | Thiostrepton-based compounds for the treatment of cancer and preparation thereof | RS肿瘤学有限责任公司 | 2025-01-10 | — | — | CN | disclosed |