Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.40 |
| ▸ | CDK8 | P49336 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 4/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16966441 | 0.89 | KDM1A (0.45) | SYKAURKAPDPK1AURKBJAK2 | |
| SCHEMBL12119790 | 0.88 | JAK3 (0.53) | BTKJAK3SYKAURKAPDPK1 | |
| SCHEMBL16966439 | 0.86 | AURKA (0.38) | CCNCCDK8AURKAPDPK1AURKB | |
| SCHEMBL12119798 | 0.83 | JAK3 (0.49) | BTKJAK3SYKAURKAPDPK1 | |
| SCHEMBL1318215 | 0.82 | KHK (0.35) | AURKAPDPK1AURKB | |
| SCHEMBL1319853 | 0.80 | AURKA (0.52) | BTKAURKAPDPK1AURKBJAK2 | |
| SCHEMBL16966467 | 0.79 | AURKA (0.36) | AURKAPDPK1AURKBKDM1A | |
| SCHEMBL12119796 | 0.78 | AURKA (0.54) | BTKJAK3SYKAURKAPDPK1 | |
| SCHEMBL3124312 | 0.77 | CCNC (0.46) | CCNCCDK8BTKJAK3PPARD | |
| SCHEMBL1318597 | 0.76 | CHRM2 (0.34) | AURKAPDPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |