Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 4/20 | 0.46 |
| ▸ | CDK8 | P49336 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 7/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119802 | 0.86 | BTK (0.59) | BTKJAK3 | |
| SCHEMBL12069784 | 0.83 | TSHR (0.57) | GAATSHRHSD17B10 | |
| SCHEMBL16966450 | 0.82 | CCNC (0.38) | CCNCCDK8LMNAGAA | |
| SCHEMBL16966480 | 0.80 | PDPK1 (0.42) | CCNCCDK8JAK3LMNA | |
| SCHEMBL14804602 | 0.79 | GALR2 (0.41) | JAK3HRH4 | |
| SCHEMBL1317316 | 0.78 | CCNC (0.37) | CCNCCDK8BTKJAK3KMT2A | |
| SCHEMBL3131514 | 0.77 | CCNC (0.40) | CCNCCDK8BTKJAK3PPARA | |
| SCHEMBL12485380 | 0.75 | HRH4 (0.41) | BTKJAK3LMNAPPARAGAA | |
| SCHEMBL16966441 | 0.75 | KDM1A (0.45) | — | |
| SCHEMBL4400365 | 0.74 | LMNA (0.42) | CCNCCDK8BTKLMNAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |