Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019978 | 1.00 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL30147734 | 0.82 | CES2 (0.59) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL531941 | 0.82 | CES2 (0.59) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL25690449 | 0.81 | HDAC1 (0.44) | HDAC6HDAC1HTTSMN1; SMN2GAA | |
| SCHEMBL8515075 | 0.79 | ESRRG (0.50) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL29306646 | 0.79 | GAA (0.58) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL25690444 | 0.79 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL30147494 | 0.79 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL1441177 | 0.79 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC2THRB | |
| SCHEMBL27909656 | 0.78 | CES2 (0.46) | HDAC6HDAC1HPGDTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |