Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316737 | 1.00 | SIRT2 (0.40) | SIRT2PIM1TRPM5SIGMAR1CA2 | |
| SCHEMBL31316656 | 0.81 | SIRT2 (0.41) | SIRT2SIGMAR1CA2ABCB1SSTR2 | |
| SCHEMBL15758209 | 0.78 | AQP1 (0.39) | TRPM5SIGMAR1CA2KDM4EALDH1A1 | |
| SCHEMBL8210999 | 0.75 | SSTR2 (0.40) | SIRT2PIM1SIGMAR1CA2ABCB1 | |
| SCHEMBL4226068 | 0.75 | AQP1 (0.49) | TRPM5SIGMAR1GRM2KDM4EALDH1A1 | |
| SCHEMBL6746035 | 0.74 | MAOB (0.56) | SIGMAR1ABCB1KDM4E | |
| SCHEMBL30997908 | 0.74 | MAOB (0.56) | SIGMAR1ABCB1KDM4E | |
| SCHEMBL9781206 | 0.71 | CYP3A4 (0.40) | GRM2 | |
| SCHEMBL4225662 | 0.70 | AQP1 (0.44) | SIRT2TRPM5KDM4EALDH1A1HPGD | |
| SCHEMBL4230244 | 0.70 | AQP1 (0.42) | TRPM5SIGMAR1GRM2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |