Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMM2 | O15305 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316881 | 0.84 | POLB (0.43) | POLBKMT2AMEN1FYNTP53 | |
| SCHEMBL31316663 | 0.81 | TP53 (0.59) | PMM2MPIPHOSPHO1TP53 | |
| SCHEMBL31316903 | 0.81 | MEN1 (0.50) | POLBKMT2AMEN1KIF11TP53 | |
| SCHEMBL31316899 | 0.79 | F2 (0.45) | PMM2MPIPHOSPHO1POLBKMT2A | |
| SCHEMBL7913106 | 0.75 | POLB (0.42) | PMM2MPIPHOSPHO1POLBKMT2A | |
| SCHEMBL2478098 | 0.74 | POLB (0.48) | PMM2MPIPHOSPHO1POLBKMT2A | |
| SCHEMBL2749512 | 0.74 | POLB (0.48) | PMM2MPIPHOSPHO1POLBKMT2A | |
| SCHEMBL11475821 | 0.72 | KMT2A (0.54) | KMT2AMEN1 | |
| SCHEMBL5958372 | 0.72 | NOTUM (0.53) | POLBKMT2AMEN1 | |
| SCHEMBL31316729 | 0.71 | MEN1 (0.41) | KMT2AMEN1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |