Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | PMM2 | O15305 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316872 | 0.84 | L3MBTL1 (0.56) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316911 | 0.82 | TP53 (0.54) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316890 | 0.82 | F2 (0.45) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316889 | 0.79 | PMM2 (0.44) | ERN1PMM2MPIPHOSPHO1KEAP1 | |
| SCHEMBL31316781 | 0.77 | ALDH1A1 (0.45) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316906 | 0.75 | LMNA (0.56) | L3MBTL1KEAP1NFE2L2LMNAMEN1 | |
| SCHEMBL31316765 | 0.74 | F2 (0.44) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316760 | 0.73 | CHRNB2 (0.60) | ALDH1A1KEAP1NFE2L2LMNAKDM4E | |
| SCHEMBL7114840 | 0.73 | F2 (0.53) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316818 | 0.72 | F2 (0.50) | F2PLAUKLKB1ELANEL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |