Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20236407 | 0.80 | NPY5R (0.50) | MCHR1NOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL20236406 | 0.80 | NPY5R (0.50) | MCHR1NOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL1750257 | 0.80 | MCHR1 (0.42) | HTR2BHTR6MCHR1NOTUMPDGFRB | |
| SCHEMBL4118087 | 0.77 | ALDH1A1 (0.50) | MCHR1PIM1PIM3PIM2 | |
| SCHEMBL4117384 | 0.77 | ALDH1A1 (0.50) | MCHR1PIM1PIM3PIM2 | |
| SCHEMBL2424720 | 0.77 | HRH4 (0.45) | MCHR1NOTUMPIM1PIM3PIM2 | |
| SCHEMBL2424717 | 0.77 | HRH4 (0.45) | MCHR1NOTUMPIM1PIM3PIM2 | |
| SCHEMBL24680813 | 0.77 | NOTUM (0.47) | MCHR1NOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL29914613 | 0.77 | NOTUM (0.47) | MCHR1NOTUMHSD11B1FPR1FPR2 | |
| SCHEMBL2421341 | 0.76 | NOTUM (0.45) | HTR2BHTR6MCHR1NOTUMPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240366615-A1 | POLQ INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 2024-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366615-A1 | POLQ INHIBITORS | POLQ, POLG, POLB | HTR2B 4539/4885HTR6 4806/4885MCHR1 4483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.