SCHEMBL31322673

SCHEMBL31322673

CSc1cc(F)cc(CO)c1C

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.32
CYP4F2 P78329 1/20 0.32
CYP4A11 Q02928 1/20 0.32
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31322752 0.82 CYP4F2 (0.33) CYP4F2CYP4A11SLC6A2SLC6A4PDE4A
SCHEMBL31322728 0.81
SCHEMBL24458092 0.75 SHBG (0.36) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL13082486 0.75 CYP4F2 (0.35) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL25612488 0.74 POLB (0.40)
SCHEMBL25616004 0.72 CYP4F2 (0.33) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL28144588 0.72 CYP4F2 (0.33) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL286513 0.72 CYP4F2 (0.33) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL16065518 0.72 CA12 (0.39)
SCHEMBL16957698 0.68 PDCD1 (0.50) SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038462-A2 INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2025-02-20 WO disclosed