SCHEMBL31322752

SCHEMBL31322752

CSc1cc(F)cc(CO)c1F

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
LMNA P02545 1/20 0.30
DDR1 Q08345 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31322673 0.82 IMPDH2 (0.32) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL16065518 0.73 CA12 (0.39) LMNA
SCHEMBL24458088 0.72 SHBG (0.36) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL29518822 0.72 RIPK1 (0.44) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL698821 0.72 RIPK1 (0.44) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL25612486 0.71 POLB (0.42) LMNA
SCHEMBL7802421 0.69 PDE4A (0.50) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL332293 0.68 GAA (0.33) CYP4F2CYP4A11PDE4APDE4BPDE4C
SCHEMBL31322728 0.67
SCHEMBL1057960 0.66 KDM4E (0.43) CYP4F2CYP4A11PDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038462-A2 INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2025-02-20 WO disclosed