Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035275 | 0.84 | LMNA (0.55) | PTPN1LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL31394853 | 0.84 | LMNA (0.55) | PTPN1LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL30037690 | 0.83 | ALDH1A1 (0.46) | PTPN1LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL25037377 | 0.83 | ALDH1A1 (0.46) | PTPN1LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL31645687 | 0.74 | — | — | |
| SCHEMBL26043758 | 0.72 | LMNA (0.46) | PTPN1LMNAHPGDALDH1A1TSHR | |
| SCHEMBL23860317 | 0.72 | LMNA (0.46) | PTPN1LMNAHPGDALDH1A1RAB9A | |
| SCHEMBL23860315 | 0.72 | LMNA (0.48) | PTPN1LMNAHPGDALDH1A1TSHR | |
| SCHEMBL4326071 | 0.71 | LMNA (0.58) | LMNAHPGDALDH1A1KDM4ETSHR | |
| SCHEMBL23866770 | 0.71 | CYP19A1 (0.44) | PTPN1LMNAHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747253-A1 | SPIROCYCLIC WRN HELICASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025014846-A1 | SPIROCYCLIC WRN HELICASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-01-16 | — | — | WO | disclosed |