SCHEMBL31330116

SCHEMBL31330116

O=c1[nH]c2cc(CO)nn2c2ncccc12

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 11/20 0.46
KDM4D Q6B0I6 2/20 0.45
CYP1A2 P05177 3/20 0.40
LDHA P00338 1/20 0.39
HPGD P15428 4/20 0.38
MAPT P10636 2/20 0.38
CYP2C19 P33261 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
AURKA O14965 1/20 0.37
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31330201 0.87 PARP1 (0.46) PARP1KDM4DCYP1A2LDHAHPGD
SCHEMBL16695720 0.80 PARP1 (0.63) PARP1KDM4DCYP1A2LDHAHPGD
SCHEMBL31330073 0.80 PARP1 (0.70) PARP1CYP1A2
SCHEMBL16695873 0.80 PARP1 (0.70) PARP1CYP1A2
SCHEMBL23500591 0.76 KDM4D (0.47) PARP1KDM4DCYP1A2LDHAHPGD
SCHEMBL23500584 0.76 ADORA3 (0.49) PARP1KDM4DCYP1A2HPGDMAPT
SCHEMBL31330209 0.75 ADORA3 (0.53) PARP1KDM4DHPGDMAPT
SCHEMBL16695658 0.73 KDM4D (0.48) PARP1KDM4DCYP1A2LDHAHPGD
SCHEMBL31330047 0.71 PARP1 (0.55) PARP1
SCHEMBL19134467 0.69 PARP1 (0.50) PARP1KDM4DCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119371425-A Nitrogen-containing heterocyclic compound, preparation method and medical application thereof 中国医药研究开发中心有限公司 2025-01-28 CN disclosed