Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 13/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330439 | 0.84 | HPGD (0.38) | ALDH1A1HTTSMN1; SMN2EGFRAKR1B10 | |
| SCHEMBL26988300 | 0.76 | EGFR (0.40) | ALDH1A1LMNAHTTEGFRAKR1B10 | |
| SCHEMBL31278641 | 0.76 | EGFR (0.40) | ALDH1A1LMNAHTTEGFRAKR1B10 | |
| SCHEMBL31279024 | 0.72 | CYP1A2 (0.38) | — | |
| SCHEMBL30784134 | 0.72 | DDR1 (0.38) | CNR1METAP2ALDH1A1LMNAHTT | |
| SCHEMBL31330641 | 0.71 | GAA (0.42) | ALDH1A1LMNAEGFRCDK9PIK3CA | |
| SCHEMBL31330766 | 0.71 | — | — | |
| SCHEMBL31559679 | 0.71 | CSNK1E (0.43) | METAP2ALDH1A1LMNASMN1; SMN2CSNK1E | |
| SCHEMBL31330668 | 0.70 | EGFR (0.35) | EGFR | |
| SCHEMBL31330465 | 0.69 | GAA (0.46) | ALDH1A1SMN1; SMN2EGFRCDK9PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |