Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 4/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34470523 | 1.00 | PIK3CA (0.38) | PIK3CAPIK3CBP2RX7SPRGSK3B | |
| SCHEMBL34470497 | 0.86 | P2RX7 (0.38) | PIK3CAPIK3CBP2RX7SPRGSK3B | |
| SCHEMBL34470619 | 0.83 | P2RX7 (0.39) | PIK3CAPIK3CBP2RX7GSK3BPDE2A | |
| SCHEMBL31330481 | 0.83 | P2RX7 (0.39) | PIK3CAPIK3CBP2RX7GSK3BPDE2A | |
| SCHEMBL34470594 | 0.81 | GSK3B (0.43) | PIK3CAPIK3CBP2RX7GSK3B | |
| SCHEMBL3716161 | 0.80 | AKT1 (0.45) | PIK3CAPIK3CBPDE10APIK3CDEIF2AK4 | |
| SCHEMBL25204783 | 0.79 | OGA (0.39) | PIK3CALMNAPDE2ANAPEPLD | |
| SCHEMBL34470524 | 0.77 | P2RX7 (0.37) | PIK3CAPIK3CBP2RX7SPRGSK3B | |
| SCHEMBL3714085 | 0.75 | PIK3CA (0.41) | PIK3CAPIK3CBLMNAPIK3CDEIF2AK4 | |
| SCHEMBL1579169 | 0.75 | PIK3CA (0.58) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026087634-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2026-04-30 | — | — | WO | disclosed |
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |